2021–22 Bayer 04 Leverkusen season

The 2021–22 season was the 118th season in the existence of Bayer 04 Leverkusen and the club's 43rd consecutive season in the top flight of German football. In addition to the domestic league, Leverkusen participated in this season's edition of the DFB-Pokal and the UEFA Europa League.

Matches
The league fixtures were announced on 25 June 2021.

Group stage
The draw for the group stage was held on 27 August 2021.

Round of 16
The draw for the round of 16 was held on 25 February 2022.

Appearances and goals
! colspan=14 style=background:#dcdcdc; text-align:center| Goalkeepers

! colspan=14 style=background:#dcdcdc; text-align:center| Defenders

! colspan=14 style=background:#dcdcdc; text-align:center| Midfielders

! colspan=14 style=background:#dcdcdc; text-align:center| Forwards

! colspan=14 style=background:#dcdcdc; text-align:center| Players transferred out during the season

Goalscorers
Last updated: 14 May 2022