1981 French Open – Women's singles

Hana Mandlíková defeated Sylvia Hanika in the final, 6–2, 6–4 to win the women's singles tennis title at the 1981 French Open. It was her second major singles title.

Chris Evert was the two-time defending champion, but lost in the semifinals to Mandlíková.

Seeds
The seeded players are listed below. Hana Mandlíková is the champion; others show the round in which they were eliminated.


 * 1) 🇺🇸 Chris Evert (semifinals)
 * 2) 🇺🇸 Martina Navratilova (quarterfinals)
 * 3) 🇺🇸 Andrea Jaeger (semifinals)
 * 4)  Hana Mandlíková (champion)
 * 5) 🇷🇴 Virginia Ruzici (quarterfinals)
 * 6)  Sylvia Hanika (finalist)
 * 7)  Mima Jaušovec (quarterfinals)
 * 8) 🇦🇺 Dianne Fromholtz (third round)
 * 9) 🇺🇸 Kathy Jordan (third round)
 * 10)  Bettina Bunge (fourth round)
 * 11) 🇺🇸 Anne Smith (fourth round)
 * 12)  Regina Maršíková (fourth round)
 * 13) 🇺🇸 Wendy White (second round)
 * 14) 🇦🇷 Ivanna Madruga (third round)
 * 15) 🇺🇸 Leslie Allen (fourth round)
 * 16) 🇬🇧 Virginia Wade (fourth round)

Key

 * Q = Qualifier
 * WC = Wild card
 * LL = Lucky loser
 * r = Retired