2005 French Open – Women's singles

Justine Henin-Hardenne defeated Mary Pierce in the final, 6–1, 6–1 to win the women's singles tennis title at the 2005 French Open. It was her second French Open title, and her first of three consecutive French Open titles. Henin became the second woman in the Open Era to win the title after saving a match point, doing so in the fourth round against Svetlana Kuznetsova (the first to do so being Anastasia Myskina the previous year, against the same opponent in the same round).

Myskina was the defending champion, but lost in the first round to María Sánchez Lorenzo. Myskina became the first French Open champion to lose in the first round of her title defense.

This was the first French Open in which future champion Ana Ivanovic competed in the main draw. In just her second major main draw appearance, she reached the quarterfinals, losing to Nadia Petrova.

Seeds
• # 🇺🇸 Lindsay Davenport (quarterfinals)

• # 🇷🇺 Maria Sharapova (quarterfinals)

• # 🇫🇷 Amélie Mauresmo (third round)

• # 🇷🇺 Elena Dementieva (fourth round)

• # 🇷🇺 Anastasia Myskina (first round)

• # 🇷🇺 Svetlana Kuznetsova (fourth round)

• # 🇷🇺 Nadia Petrova (semifinals)

• # Patty Schnyder (fourth round)

• # 🇷🇺 Vera Zvonareva (third round)

• # 🇧🇪 Justine Henin-Hardenne (champion)

• # 🇺🇸 Venus Williams (third round)

• # 🇷🇺 Elena Bovina (fourth round)

• # 🇫🇷 Nathalie Dechy (third round)

• # 🇧🇪 Kim Clijsters (fourth round)

• # Jelena Janković (first round)

• # 🇷🇺 Elena Likhovtseva (semifinals)

• # 🇫🇷 Tatiana Golovin (third round)

• # 🇮🇹 Silvia Farina Elia (third round)

• # 🇯🇵 Shinobu Asagoe (second round)

• # 🇸🇰 Daniela Hantuchová (third round)

• # 🇫🇷 Mary Pierce (final)

• # 🇮🇹 Francesca Schiavone (fourth round)

• # 🇯🇵 Ai Sugiyama (first round)

• # 🇧🇬 Magdalena Maleeva (second round)

• # 🇷🇺 Dinara Safina (first round)

• # 🇦🇷 Paola Suárez (first round)

• # 🇺🇸 Amy Frazier (second round)

• # 🇫🇷 Marion Bartoli (first round)

• # Ana Ivanovic (quarterfinals)

• # 🇦🇷 Gisela Dulko (second round)

• # Karolina Šprem (second round)

• # 🇮🇹 Flavia Pennetta (third round)