2006 French Open – Women's singles

Defending champion Justine Henin-Hardenne defeated Svetlana Kuznetsova in the final, 6–4, 6–4 to win the women's singles tennis title at the 2006 French Open. It was her third French Open title and fifth major title overall. She won the title without losing a set during the tournament, and without facing a tiebreak in any set.

This was the first French Open main draw appearance for future champion and world No. 2 Li Na, who lost in the third round to Svetlana Kuznetsova.

Seeds
• # 🇫🇷 Amélie Mauresmo (fourth round)

• # 🇧🇪 Kim Clijsters (semifinals)

• # 🇷🇺 Nadia Petrova (first round)

• # 🇷🇺 Maria Sharapova (fourth round)

• # 🇧🇪 Justine Henin-Hardenne (champion)

• # 🇷🇺 Elena Dementieva (third round)

• # Patty Schnyder (fourth round)

• # 🇷🇺 Svetlana Kuznetsova (final)

• # 🇮🇹 Francesca Schiavone (fourth round)

• # 🇷🇺 Anastasia Myskina (fourth round)

• # 🇺🇸 Venus Williams (quarterfinals)

• # Martina Hingis (quarterfinals)

• # 🇩🇪 Anna-Lena Grönefeld (quarterfinals)

• # 🇷🇺 Dinara Safina (quarterfinals)

• # 🇸🇰 Daniela Hantuchová (fourth round)

• # 🇨🇿 Nicole Vaidišová (semifinals)

• # 🇮🇹 Flavia Pennetta (third round)

• # 🇷🇺 Elena Likhovtseva (first round)

• # Ana Ivanovic (third round)

• # 🇷🇺 Maria Kirilenko (third round)

• # 🇫🇷 Nathalie Dechy (third round)

• # 🇯🇵 Ai Sugiyama (second round)

• # 🇫🇷 Tatiana Golovin (first round)

• # Katarina Srebotnik (third round)

• # 🇫🇷 Marion Bartoli (second round)

• # 🇪🇸 Anabel Medina Garrigues (third round)

• # 🇷🇺 Anna Chakvetadze (second round)

• # 🇨🇿 Lucie Šafářová (first round)

• # 🇸🇪 Sofia Arvidsson (second round)

• # 🇨🇿 Klára Koukalová (first round)

• # 🇮🇱 Shahar Pe'er (fourth round)

• # 🇦🇷 Gisela Dulko (fourth round)