2012 Mutua Madrid Open – Women's singles

Serena Williams defeated Victoria Azarenka in the final, 6–1, 6–3 to win the women's singles tennis title at the 2012 Madrid Open. It was Azarenka's second consecutive runner-up finish at the event.

Petra Kvitová was the defending champion, but lost to Lucie Hradecká in the second round.

Seeds
🇧🇾 Victoria Azarenka (final) 🇷🇺 Maria Sharapova (quarterfinals) 🇨🇿 Petra Kvitová (second round) 🇵🇱 Agnieszka Radwańska (semifinals) 🇦🇺 Samantha Stosur (quarterfinals) Caroline Wozniacki (third round) 🇫🇷 Marion Bartoli (first round) 🇨🇳 Li Na (quarterfinals)

🇺🇸 Serena Williams (champion) 🇷🇺 Vera Zvonareva (first round) 🇮🇹 Francesca Schiavone (first round) 🇩🇪 Angelique Kerber (third round) 🇷🇸 Ana Ivanovic (third round) 🇸🇰 Dominika Cibulková (first round) 🇷🇸 Jelena Janković (first round) 🇷🇺 Maria Kirilenko (second round)

Seeds
• # 🇫🇷 Pauline Parmentier (qualifying competition)

• # 🇨🇿 Barbora Záhlavová-Strýcová (first round)

• # Eleni Daniilidou (first round)

• # Hsieh Su-wei (qualifying competition)

• # 🇭🇺 Gréta Arn (first round)

• # 🇷🇺 Vera Dushevina (first round)

• # 🇺🇸 Varvara Lepchenko (qualified)

• # 🇸🇪 Johanna Larsson (qualified)

• # 🇺🇸 Sloane Stephens (first round)

• # 🇫🇷 Mathilde Johansson (qualified)

• # 🇦🇺 Anastasia Rodionova (qualified)

• # 🇨🇿 Lucie Hradecká (qualified)

• # 🇷🇸 Bojana Jovanovski (first round)

• # 🇪🇸 Laura Pous Tió (qualifying competition)

• # 🇺🇸 Bethanie Mattek-Sands (first round)

• # 🇪🇸 Lourdes Domínguez Lino (qualified)

Qualifiers
• # 🇦🇺 Anastasia Rodionova

• # 🇫🇷 Mathilde Johansson

• # 🇺🇸 Jill Craybas

• # 🇨🇿 Andrea Hlaváčková

• # 🇨🇿 Lucie Hradecká

• # 🇪🇸 Lourdes Domínguez Lino

• # 🇺🇸 Varvara Lepchenko

• # 🇸🇪 Johanna Larsson