2023 Eastern Illinois Panthers football team

The 2023 Eastern Illinois Panthers football team represented Eastern Illinois University as a member of the Big South–OVC Football Association during the 2023 NCAA Division I FCS football season. Led by second-year head coach Chris Wilkerson, the Panthers played home games at O'Brien Field in Charleston, Illinois.

Preseason coaches' poll
The Big South-OVC released their preseason coaches' poll on July 25, 2023. The Panthers were picked to finish in eighth place.

Preseason Watchlist
The Panthers had ten players selected to the preseason Big South-OVC watchlist.