COUP-TFI

COUP-TF1 ( COUP T ranscription F actor 1 ) also known as NR2F1 ( N uclear R eceptor subfamily 2, group F , member 1 ) is a protein that in humans is encoded by the NR2F1 gene. This protein is a member of nuclear hormone receptor family of steroid hormone receptors.

Function
Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. COUP-TF1 binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif.

Interactions
COUP-TFI has been shown to interact with:
 * BCL11A,
 * BCL11B,
 * COPS2, and
 * ESR1.

Clinical
Mutations in this gene have been associated with Bosch-Boonstra-Schaaf optic atrophy syndrome.