Y box binding protein 1

Y box binding protein 1 also known as Y-box transcription factor or nuclease-sensitive element-binding protein 1 is a protein that in humans is encoded by the YBX1 gene. YBX1 is an RNA binding protein that stabilises messenger RNAs modified with N6-methyladenosine.

Clinical significance
YBX1 is a potential drug target in cancer therapy. YB-1 helps the replication of adenovirus type 5, a commonly used vector in gene therapy. Thus, YB-1 can cause an "oncolytic" effect in YB-1 positive cancer cells treated with adenoviruses.

Interactions
Y box binding protein 1 has been shown to interact with:


 * ANKRD2,
 * CTCF,
 * P53,
 * PCNA,
 * RBBP6, and
 * SFRS9.