Zinc finger and BTB domain-containing protein 16

Zinc finger and BTB domain-containing protein 16 is a protein that in humans is encoded by the ZBTB16 gene.

Function
This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL) and physiological roles have been identified in mouse Natural Killer T cells and gamma-delta T cells. Alternate transcriptional splice variants have been characterized in human.

Interactions
Zinc finger and BTB domain-containing protein 16 has been shown to interact with:


 * Angiotensin II receptor type 1,
 * BCL6,
 * BMI1,
 * Calcitriol receptor,
 * FHL2,
 * GATA1,
 * GATA2,
 * HDAC1,
 * HDAC4,
 * HDAC5,
 * HDAC6,
 * Heparin-binding EGF-like growth factor,
 * Nuclear receptor co-repressor 2,
 * Promyelocytic leukemia protein
 * RUNX1T1,
 * Retinoic acid receptor alpha,
 * SIN3A,
 * SIN3B, and
 * ZBTB32.