1995 Cal Poly Mustangs football team

The 1995 Cal Poly Mustangs football team represented California Polytechnic State University during the 1995 NCAA Division I-AA football season.

Cal Poly competed in the last year of the American West Conference (AWC). They would compete as a Division I-AA Independent starting in 1996. The 1995 Mustangs were led by second-year head coach Andre Patterson and played home games at Mustang Stadium in San Luis Obispo, California. They finished the season with a record of five wins and six losses (5–6, 2–1 AWC). Overall, the team outscored its opponents 411–271 for the season.