GPR124

Probable G-protein coupled receptor 124 is a protein that in humans is encoded by the GPR124 gene. It is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

Interactions
GPR124 has been shown to interact with DLG1 and is involved in the Wnt/β-catenin signaling pathway along with RECK. GPR124 is the predicted target of several Group IV (+)ssRNA neuroinvasive viruses; proteolytic cleavage of GPR124 by these viral proteases may be important for entry into the brain.

Zebrafish embryos with Gpr124 loss of function demonstrate severe angiogenic deficiencies in the central nervous system.