GPR143

G-protein coupled receptor 143, also known as Ocular albinism type 1 (OA1) in humans, is a conserved integral membrane protein with seven transmembrane domains and similarities with G protein-coupled receptors (GPCRs) that is expressed in the eye and epidermal melanocytes. This protein encoded by the GPR143 gene, whose variants can lead to Ocular albinism type 1.

The GPR143 gene is regulated by the Microphthalmia-associated transcription factor.

L-DOPA is an endogenous ligand for OA1.

Interactions
GPR143 has been shown to interact with GNAI1.