C5a receptor

The C5a receptor also known as complement component 5a receptor 1 (C5AR1) or CD88 (Cluster of Differentiation 88) is a G protein-coupled receptor for C5a. It functions as a complement receptor. C5a receptor 1 modulates inflammatory responses, obesity, development and cancers. From a signaling transduction perspective, C5a receptor 1 activation is implicated in β-arrestin2 recruitment via Rab5a, coupling of Gαi proteins, ERK1/2 phosphorylation, calcium mobilization and Rho activation leading to downstream functions, such as secretion of cytokines, chemotaxis, and phagocytosis.



Cells
The C5a receptor 1 is expressed on:
 * Granulocytes
 * Macrophages
 * Monocytes
 * Dendritic cells
 * Hepatoma-derived cell line HepG2
 * Astrocytes
 * Microglia

Agonist and antagonists
Potent and selective agonist and antagonists for C5a receptor 1 have been developed.