S1PR4

Sphingosine-1-phosphate receptor 4 also known as S1PR4 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P4.

Function
This gene is a member of the endothelial differentiation, G-protein-coupled (EDG) receptor gene family. EDG receptors bind lysophospholipids or lysosphingolipids as ligands, and are involved in cell signalling in many different cell types. This EDG receptor gene is intronless and is specifically expressed in the lymphoid tissue.

Evolution
=== Paralogues to S1PR4 Gene ===


 * S1PR5
 * S1PR3
 * S1PR1
 * S1PR2
 * LPAR2
 * LPAR1
 * LPAR3
 * CNR1
 * GPR6
 * CNR2
 * GPR3
 * GPR12
 * MC4R
 * MC5R
 * MC3R
 * MC2R
 * MC1R
 * GPR119