GPR139

G-protein coupled receptor 139 (GPC139) is a protein that in humans is encoded by the GPR139 gene. Research has shown that mice with loss of GCP139 experience schizophrenia-like symptomatology that is rescued with the dopamine receptor antagonist haloperidol and the μ-opioid receptor antagonist naltrexone.

Ligands

 * Agonists
 * Zelatriazin (TAK-41), (NBI-1065846) a potent, and GPR139 receptor selective agonist which was in clinical trials to gauge the efficacy for treating psychiatric conditions such as major depressive disorder and the negative symptoms of schizophrenia, but was later dropped from development.


 * Antagonists
 * JNJ-3792165