2020 US Open – Women's doubles

Elise Mertens and Aryna Sabalenka were the defending champions, but lost in the quarterfinals to Laura Siegemund and Vera Zvonareva.

Siegemund and Zvonareva went on to win the title in their first event together, beating Nicole Melichar and Xu Yifan in the final, 6–4, 6–4. This was the first time since 2006 that an unseeded team won the US Open women's doubles titles; incidentally, Zvonareva was part of this unseeded team. This was Zvonareva's third Grand Slam title in women's doubles, fifth Grand Slam title overall, her first Grand Slam title since the 2012 Australian Open women's doubles, and her first U.S. Open title since the aforementioned title in 2006. It was Siegemund's first Grand Slam women's doubles title, and her second Grand Slam title overall.

Seeds
• 🇭🇺 Tímea Babos / 🇫🇷 Kristina Mladenovic (second round, withdrew, due to COVID-19)

• 🇧🇪 Elise Mertens / 🇧🇾 Aryna Sabalenka (quarterfinals)

• 🇺🇸 Nicole Melichar / 🇨🇳 Xu Yifan (final)

• 🇨🇿 Květa Peschke /  Demi Schuurs (quarterfinals)

• 🇺🇸 Bethanie Mattek-Sands / 🇨🇳 Zhang Shuai (first round)

• 🇯🇵 Shuko Aoyama / 🇯🇵 Ena Shibahara (second round)

• 🇧🇾 Victoria Azarenka / 🇺🇸 Sofia Kenin (second round)

• 🇩🇪 Anna-Lena Friedsam / 🇨🇿 Kateřina Siniaková (second round)

Wild cards
• 🇺🇸 Usue Maitane Arconada / 🇺🇸 Christina McHale

• 🇺🇸 Hailey Baptiste / 🇺🇸 Whitney Osuigwe

• 🇺🇸 Ann Li / 🇺🇸 Bernarda Pera

• 🇺🇸 Jessica Pegula / 🇺🇸 Shelby Rogers

Protected ranking
• 🇷🇺 Natela Dzalamidze / 🇷🇺 Irina Khromacheva

• 🇩🇪 Laura Siegemund / 🇷🇺 Vera Zvonareva (Winner)