2021 US Open – Women's doubles

Samantha Stosur and Zhang Shuai defeated Coco Gauff and Caty McNally in the final, 6–3, 3–6, 6–3 to win the women's doubles title at the 2021 US Open. It was Stosur's fourth major title in women's doubles and eighth major overall, as well as Zhang's second major title; this was the team's second major title, following the 2019 Australian Open. This was the first major final for Gauff and for McNally.

Laura Siegemund and Vera Zvonareva were the reigning champions, but Siegemund did not participate due to injury. Zvonareva was scheduled to play partnering Jeļena Ostapenko, but Ostapenko withdrew from both the singles and doubles draws on the first day of the tournament.

Hsieh Su-wei regained the WTA No. 1 doubles ranking from her partner Elise Mertens after Barbora Krejčíková lost in the first round.

This was the final tournament for former WTA Finals finalist, 2014 French Open semifinalist and former doubles world No. 11 Carla Suárez Navarro. She partnered Sara Errani, but lost in the first round to Gauff and McNally.

Seeds
• Hsieh Su-wei / 🇧🇪 Elise Mertens (quarterfinals)

• 🇨🇿 Barbora Krejčíková / 🇨🇿 Kateřina Siniaková (first round)

• 🇯🇵 Shuko Aoyama / 🇯🇵 Ena Shibahara (third round)

• 🇺🇸 Nicole Melichar-Martinez / Demi Schuurs (first round)

• 🇨🇦 Gabriela Dabrowski / 🇧🇷 Luisa Stefani (semifinals, retired)

• 🇷🇺 Veronika Kudermetova / 🇺🇸 Bethanie Mattek-Sands (third round)

•  Alexa Guarachi / 🇺🇸 Desirae Krawczyk (semifinals)

•  Darija Jurak /  Andreja Klepač (third round)

•  Jeļena Ostapenko / 🇷🇺 Vera Zvonareva (withdrew)

• 🇺🇸 Caroline Dolehide / 🇦🇺 Storm Sanders (quarterfinals)

• 🇺🇸 Coco Gauff / 🇺🇸 Caty McNally (final)

• 🇺🇦 Nadiia Kichenok / 🇷🇴 Raluca Olaru (third round)

• 🇺🇸 Asia Muhammad / 🇺🇸 Jessica Pegula (first round)

• 🇦🇺 Samantha Stosur / 🇨🇳 Zhang Shuai (champions)

• 🇨🇿 Marie Bouzková / 🇨🇿 Lucie Hradecká (quarterfinals)

• 🇦🇺 Ellen Perez / 🇨🇿 Květa Peschke (second round)

• 🇷🇸 Aleksandra Krunić / 🇷🇸 Nina Stojanović (second round)

Wild cards
• 🇺🇸 Usue Maitane Arconada / 🇺🇸 Whitney Osuigwe

• 🇺🇸 Hailey Baptiste / 🇺🇸 Emma Navarro

• 🇺🇸 Madison Brengle / 🇺🇸 Claire Liu

• 🇺🇸 Lauren Davis / 🇺🇸 Ingrid Neel

• 🇺🇸 Makenna Jones / 🇺🇸 Elizabeth Scotty

• 🇺🇸 Ashlyn Krueger / 🇺🇸 Robin Montgomery

• 🇮🇳 Sania Mirza / 🇺🇸 CoCo Vandeweghe

Protected ranking
• 🇰🇿 Anna Danilina / 🇰🇿 Yaroslava Shvedova

• 🇯🇵 Eri Hozumi / 🇵🇱 Alicja Rosolska

• 🇷🇸 Ivana Jorović / Lesley Pattinama Kerkhove

• 🇱🇺 Mandy Minella / 🇷🇺 Liudmila Samsonova

• 🇦🇺 Anastasia Rodionova / 🇦🇺 Arina Rodionova

• 🇧🇾 Aliaksandra Sasnovich / 🇰🇿 Galina Voskoboeva

Alternates
• 🇺🇸 Emina Bektas / 🇬🇧 Tara Moore

• 🇺🇦 Kateryna Bondarenko / 🇮🇳 Ankita Raina

• 🇰🇿 Zarina Diyas / 🇷🇺 Varvara Gracheva

• 🇳🇴 Ulrikke Eikeri / 🇫🇷 Elixane Lechemia

• 🇮🇹 Sara Errani / 🇪🇸 Carla Suárez Navarro

Withdrawals

 * Before the tournament
 * 🇺🇸 Amanda Anisimova / 🇷🇺 Anastasia Potapova → replaced by 🇳🇴 Ulrikke Eikeri / 🇫🇷 Elixane Lechemia
 * 🇪🇸 Paula Badosa / 🇪🇸 Sara Sorribes Tormo → replaced by 🇺🇦 Kateryna Bondarenko / 🇮🇳 Ankita Raina
 * 🇷🇺 Anna Blinkova / 🇬🇧 Heather Watson → replaced by 🇰🇿 Zarina Diyas / 🇷🇺 Varvara Gracheva
 * Jeļena Ostapenko / 🇷🇺 Vera Zvonareva → replaced by 🇮🇹 Sara Errani / 🇪🇸 Carla Suárez Navarro
 * 🇷🇺 Anastasia Pavlyuchenkova / 🇰🇿 Elena Rybakina → replaced by 🇺🇸 Emina Bektas / 🇬🇧 Tara Moore