2010 US Open – Women's doubles

Serena Williams and Venus Williams were the defending champions. However, Serena withdrew from the tournament because of a foot injury and Venus chose to participate in the singles event only. Vania King and Yaroslava Shvedova defeated Liezel Huber and Nadia Petrova 2–6, 6–4, 7–6(7–4) in the final. This match was played over two days due to heavy rainfall on September 12.

Seeds
• # 🇦🇷 Gisela Dulko / 🇮🇹 Flavia Pennetta (quarterfinals)

• # 🇺🇸 Liezel Huber / 🇷🇺 Nadia Petrova (final)

• # 🇪🇸 Nuria Llagostera Vives / 🇪🇸 María José Martínez Sánchez (first round)

• # 🇨🇿 Květa Peschke / Katarina Srebotnik (third round)

• # 🇺🇸 Lisa Raymond / 🇦🇺 Rennae Stubbs (quarterfinals)

• # 🇺🇸 Vania King / 🇰🇿 Yaroslava Shvedova (champions)

• # Chan Yung-jan / 🇨🇳 Zheng Jie (semifinals)

• # 🇪🇸 Anabel Medina Garrigues / 🇨🇳 Yan Zi (second round)

• # Cara Black / 🇦🇺 Anastasia Rodionova (semifinals)

• # 🇷🇺 Maria Kirilenko / 🇵🇱 Agnieszka Radwańska (third round)

• # 🇷🇺 Alisa Kleybanova / 🇷🇺 Ekaterina Makarova (second round)

• # 🇨🇿 Iveta Benešová / 🇨🇿 Barbora Záhlavová-Strýcová (third round)

• # 🇷🇴 Monica Niculescu / 🇮🇱 Shahar Pe'er (third round)

• # 🇷🇺 Elena Vesnina / 🇷🇺 Vera Zvonareva (quarterfinals)

• # 🇺🇸 Bethanie Mattek-Sands / 🇺🇸 Meghann Shaughnessy (quarterfinals)

• # Hsieh Su-wei / 🇨🇳 Peng Shuai (second round)