2022 US Open – Women's doubles

Barbora Krejčíková and Kateřina Siniaková defeated Caty McNally and Taylor Townsend in the final, 3–6, 7–5, 6–1 to win the women's doubles tennis title at the 2022 US Open. With the win, they became the first women's pair (and the third and fourth women overall, after Gigi Fernández and Pam Shriver) to complete the career Super Slam in doubles. It was their sixth major title together.

Samantha Stosur and Zhang Shuai were the defending champions, but did not compete together. Stosur partnered Latisha Chan, but lost to Miyu Kato and Aldila Sutjiadi in the first round. Zhang partnered Marta Kostyuk, but lost to Desirae Krawczyk and Demi Schuurs in the third round.

Siniaková regained the WTA number 1 doubles ranking at the end of the tournament. Coco Gauff, Elise Mertens, Jeļena Ostapenko and Giuliana Olmos were also in contention for the top ranking.

This tournament marked the final professional doubles appearance for 14-time major doubles champion, three-time Olympic doubles gold medalist, and former doubles world No. 1 Serena Williams; partnering with her sister Venus Williams, she lost in the first round to Lucie Hradecká and Linda Nosková.

This was the first edition of US Open to feature a 10-point tie-break, when the score reaches six games all in the deciding set. Lyudmyla Kichenok and Ostapenko defeated Panna Udvardy and Tamara Zidanšek in the first round in the first women's doubles main-draw 10-point tie-break at US Open.

Seeds
• Veronika Kudermetova / 🇧🇪 Elise Mertens (second round, withdrew)

• 🇺🇸 Coco Gauff / 🇺🇸 Jessica Pegula (first round)

• 🇨🇿 Barbora Krejčíková / 🇨🇿 Kateřina Siniaková (champions)

• 🇺🇦 Lyudmyla Kichenok / Jeļena Ostapenko (third round)

• 🇨🇦 Gabriela Dabrowski / 🇲🇽 Giuliana Olmos (quarterfinals)

• 🇺🇸 Desirae Krawczyk /  Demi Schuurs (quarterfinals)

• 🇨🇳 Xu Yifan / 🇨🇳 Yang Zhaoxuan (third round)

• 🇰🇿 Anna Danilina / 🇧🇷 Beatriz Haddad Maia (third round)

• 🇺🇸 Asia Muhammad / 🇯🇵 Ena Shibahara (third round)

• 🇺🇸 Nicole Melichar-Martinez / 🇦🇺 Ellen Perez (semifinals)

• 🇺🇦 Marta Kostyuk / 🇨🇳 Zhang Shuai (third round)

• 🇺🇸 Caroline Dolehide / 🇦🇺 Storm Sanders (semifinals)

•  Alexa Guarachi /  Andreja Klepač (third round)

• 🇫🇷 Caroline Garcia / 🇫🇷 Kristina Mladenovic (quarterfinals)

• 🇯🇵 Shuko Aoyama /  Chan Hao-ching (third round)

• 🇵🇱 Alicja Rosolska / 🇳🇿 Erin Routliffe (second round)

Wild cards
• 🇺🇸 Hailey Baptiste / 🇺🇸 Whitney Osuigwe

• 🇺🇸 Reese Brantmeier / 🇺🇸 Clervie Ngounoue

• 🇺🇸 Sophie Chang / 🇺🇸 Angela Kulikov

• 🇺🇸 Ashlyn Krueger / 🇺🇸 Peyton Stearns

• 🇺🇸 Elizabeth Mandlik / 🇺🇸 Katrina Scott

• 🇺🇸 Robin Montgomery / 🇺🇸 CoCo Vandeweghe

• 🇺🇸 Serena Williams / 🇺🇸 Venus Williams

Protected ranking
• 🇺🇸 Sofia Kenin / 🇦🇺 Ajla Tomljanović

• 🇦🇷 Nadia Podoroska / 🇪🇬 Mayar Sherif

• 🇰🇿 Yulia Putintseva / 🇧🇪 Yanina Wickmayer

• Rosalie van der Hoek / 🇧🇪 Alison Van Uytvanck

Alternates
• 🇬🇧 Alicia Barnett / 🇬🇧 Olivia Nicholls

• 🇺🇸 Catherine Harrison / 🇺🇸 Ingrid Neel

• 🇨🇳 Han Xinyun / Evgeniya Rodina

• 🇨🇳 Wang Xinyu / 🇨🇳 Zhu Lin

Withdrawals

 * 🇨🇿 Marie Bouzková / 🇩🇪 Laura Siegemund → replaced by 🇨🇳 Han Xinyun / Evgeniya Rodina
 * 🇨🇿 Lucie Hradecká / 🇮🇳 Sania Mirza → replaced by 🇨🇿 Lucie Hradecká / 🇨🇿 Linda Nosková
 * 🇺🇦 Anhelina Kalinina / 🇰🇿 Elena Rybakina → replaced by 🇺🇸 Catherine Harrison / 🇺🇸 Ingrid Neel
 * 🇪🇪 Anett Kontaveit / 🇺🇸 Shelby Rogers → replaced by 🇬🇧 Alicia Barnett / 🇬🇧 Olivia Nicholls
 * 🇮🇹 Jasmine Paolini / 🇮🇹 Martina Trevisan → replaced by 🇨🇳 Wang Xinyu / 🇨🇳 Zhu Lin