2008 US Open – Women's doubles

Nathalie Dechy and Dinara Safina were the defending champions, but Safina chose not to participate, and only Dechy competed that year.

Dechy partnered with Casey Dellacqua, but lost in the first round to Klaudia Jans and Alicja Rosolska.

Cara Black and Liezel Huber won in the final 6–3, 7–6(8–6), against Lisa Raymond and Samantha Stosur.

Seeds
• # Cara Black / 🇺🇸 Liezel Huber (champions)

• # 🇨🇿 Květa Peschke / 🇦🇺 Rennae Stubbs (first round)

• # Chan Yung-jan /  Chuang Chia-jung (first round)

• # Katarina Srebotnik / 🇯🇵 Ai Sugiyama (semifinals)

• # 🇪🇸 Anabel Medina Garrigues / 🇪🇸 Virginia Ruano Pascual (semifinals)

• # 🇧🇾 Victoria Azarenka / 🇮🇱 Shahar Pe'er (first round)

• # 🇺🇦 Alona Bondarenko / 🇺🇦 Kateryna Bondarenko (third round)

• # 🇨🇳 Yan Zi / 🇨🇳 Zheng Jie (quarterfinals)

• # 🇫🇷 Nathalie Dechy / 🇦🇺 Casey Dellacqua (first round)

• # 🇺🇸 Lisa Raymond / 🇦🇺 Samantha Stosur (final)

• # 🇸🇰 Janette Husárová / 🇨🇳 Peng Shuai (third round)

• # 🇨🇿 Iveta Benešová / 🇷🇺 Galina Voskoboeva (second round)

• # 🇷🇺 Elena Vesnina / 🇷🇺 Vera Zvonareva (second round)

• # 🇪🇸 Nuria Llagostera Vives / 🇪🇸 María José Martínez Sánchez (second round)

• # 🇷🇺 Maria Kirilenko / 🇮🇹 Flavia Pennetta (first round)

• # 🇨🇿 Eva Hrdinová / 🇨🇿 Vladimíra Uhlířová (first round)