2021–22 SS Lazio season

The 2021–22 season was the 122nd season in the existence of S.S. Lazio and the club's 34th consecutive season in the top flight of Italian football. In addition to the domestic league, Lazio participated in this season's editions of the Coppa Italia and the UEFA Europa League.

Matches
The league fixtures were announced on 14 July 2021.

Group stage
The draw for the group stage was held on 27 August 2021.

Knockout round play-offs
The knockout round play-offs draw was held on 13 December 2021. 

Appearances and goals
! colspan=14 style="background:#B2FFFF; text-align:center"| Goalkeepers

! colspan=14 style="background:#B2FFFF; text-align:center"| Defenders

! colspan=14 style="background:#B2FFFF; text-align:center"| Midfielders

! colspan=14 style="background:#B2FFFF; text-align:center"| Forwards

! colspan=14 style="background:#B2FFFF; text-align:center"| Players transferred out during the season