2022 Mexico City Open

The 2022 Mexico City Open was a professional tennis tournament played on clay courts. It was the first edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Mexico City, Mexico between 4 and 10 April 2022.

Seeds

 * 1 Rankings are as of 21 March 2022.

Other entrants
The following players received wildcards into the singles main draw:
 * 🇲🇽 Luis Carlos Álvarez
 * 🇲🇽 Alex Hernández
 * Nicolás Jarry

The following players received entry into the singles main draw as alternates:
 * 🇳🇴 Viktor Durasovic
 * 🇺🇿 Denis Istomin
 * 🇷🇸 Peđa Krstin
 * 🇦🇺 Bernard Tomic

The following players received entry from the qualifying draw:
 * 🇧🇷 Mateus Alves
 * 🇨🇴 Nicolás Barrientos
 * 🇺🇸 Nick Chappell
 * 🇩🇪 Elmar Ejupovic
 * 🇧🇷 Gilbert Klier Júnior
 * 🇺🇸 Keegan Smith

Singles

 * Marc-Andrea Hüsler def. 🇦🇷 Tomás Martín Etcheverry 6–4, 6–2.

Doubles

 * Nicolás Jarry / 🇧🇷 Matheus Pucinelli de Almeida def. 🇫🇷 Jonathan Eysseric / 🇳🇿 Artem Sitak 6–2, 6–3.