2008 Sony Ericsson Open – Women's singles

Defending champion Serena Williams defeated Jelena Janković in the final, 6–1, 5–7, 6–3 to win the women's singles tennis title at the 2008 Miami Open. It was her fifth Miami Open title, tying Steffi Graf's record.

Seeds
All seeds received a bye into the second round. • # 🇧🇪 Justine Henin (quarterfinals)

• # 🇷🇸 Ana Ivanovic (third round)

• # 🇷🇺 Svetlana Kuznetsova (semifinals)

• # 🇷🇸 Jelena Janković (final)

• # 🇷🇺 Anna Chakvetadze (third round)

• # 🇺🇸 Venus Williams (quarterfinals)

• # 🇸🇰 Daniela Hantuchová (third round)

• # 🇺🇸 Serena Williams (champion)

• # 🇫🇷 Marion Bartoli (second round)

• # 🇷🇺 Elena Dementieva (quarterfinals, retired due to a mid-back injury)

• # Patty Schnyder (third round)

• # 🇨🇿 Nicole Vaidišová (second round)

• # 🇷🇺 Dinara Safina (quarterfinals)

• # 🇷🇺 Nadia Petrova (second round, retired due to a right quad strain)

• # 🇭🇺 Ágnes Szávay (second round)

• # 🇮🇱 Shahar Pe'er (fourth round)

• # 🇵🇱 Agnieszka Radwańska (second round)

• # 🇦🇹 Sybille Bammer (third round)

• # 🇷🇺 Vera Zvonareva (semifinals)

• # 🇮🇹 Francesca Schiavone (second round)

• # 🇺🇦 Alona Bondarenko (second round)

• # Katarina Srebotnik (third round)

• # 🇫🇷 Virginie Razzano (second round)

• # 🇫🇷 Amélie Mauresmo (third round)

• # 🇧🇾 Victoria Azarenka (third round)

• # 🇷🇺 Maria Kirilenko (second round)

• # 🇮🇹 Flavia Pennetta (third round)

• # 🇪🇸 Anabel Medina Garrigues (second round)

• # 🇮🇳 Sania Mirza (withdrew due to a right wrist injury)

• # Michaëlla Krajicek (second round)

• # 🇮🇹 Karin Knapp (second round)

• # 🇺🇸 Lindsay Davenport (fourth round)

Qualifying seeds
• # Timea Bacsinszky (first round)

• # 🇺🇦 Mariya Koryttseva (qualifying competition, Lucky loser)

• # 🇦🇷 María Emilia Salerni (first round)

• # 🇷🇺 Anastasia Rodionova (qualified)

• # 🇹🇭 Tamarine Tanasugarn (qualifying competition, Lucky loser)

• # 🇷🇺 Alisa Kleybanova (qualified)

• # 🇨🇳 Yuan Meng (qualifying competition)

• # 🇯🇵 Aiko Nakamura (qualified)

• # 🇺🇸 Julie Ditty (first round)

• # 🇨🇿 Petra Cetkovská (qualifying competition)

• # 🇺🇸 Lilia Osterloh (qualifying competition)

• # 🇺🇦 Olga Savchuk (qualified)

• # Hsieh Su-wei (first round)

• # 🇷🇺 Alla Kudryavtseva (qualifying competition)

• # 🇨🇴 Catalina Castaño (first round)

• # 🇷🇺 Ekaterina Bychkova (qualified)

• # 🇱🇺 Anne Kremer (qualifying competition)

• # 🇷🇺 Olga Puchkova (first round)

• # 🇺🇦 Yuliana Fedak (first round)

• # 🇷🇺 Galina Voskoboeva (qualified)

• # 🇮🇹 Maria Elena Camerin (first round)

• # 🇩🇪 Sandra Klösel (first round)

• # 🇯🇵 Ayumi Morita (first round)

• # Rossana de los Ríos (qualified)

Qualifiers
• # 🇷🇺 Galina Voskoboeva

• # 🇷🇺 Ekaterina Bychkova

• # 🇨🇿 Petra Kvitová

• # 🇷🇺 Anastasia Rodionova

• # Rossana de los Ríos

• # 🇷🇺 Alisa Kleybanova

• # 🇧🇾 Tatiana Poutchek

• # 🇯🇵 Aiko Nakamura

• # 🇺🇸 Vania King

• # 🇨🇦 Aleksandra Wozniak

• # Emmanuelle Gagliardi

• # 🇺🇦 Olga Savchuk

Lucky losers
• # 🇺🇦 Mariya Koryttseva

• # 🇹🇭 Tamarine Tanasugarn