2009 Sony Ericsson Open – Women's singles

Victoria Azarenka defeated the two-time defending champion Serena Williams in the final, 6–3, 6–1 to win the women's singles tennis title at the 2009 Miami Open. It was her third WTA Tour singles title, and first at the Premier or above level.

Seeds
All seeds received a bye into the second round. • # 🇺🇸 Serena Williams (final)

• # 🇷🇺 Dinara Safina (third round)

• # 🇷🇸 Jelena Janković (second round)

• # 🇷🇺 Elena Dementieva (fourth round)

• # 🇺🇸 Venus Williams (semifinals)

• # 🇷🇺 Vera Zvonareva (third round)

• # 🇷🇸 Ana Ivanovic (third round)

• # 🇷🇺 Svetlana Kuznetsova (semifinals)

• # 🇷🇺 Nadia Petrova (third round)

• # 🇵🇱 Agnieszka Radwańska (fourth round)

• # 🇧🇾 Victoria Azarenka (champion)

• # 🇫🇷 Marion Bartoli (second round)

• # Caroline Wozniacki (quarterfinals)

• # 🇫🇷 Alizé Cornet (third round)

• # 🇮🇹 Flavia Pennetta (third round)

• # 🇸🇰 Dominika Cibulková (third round, retired to due cramping)

• # 🇨🇳 Zheng Jie (fourth round)

• # Patty Schnyder (third round)

• # 🇪🇸 Anabel Medina Garrigues (fourth round)

• # 🇫🇷 Amélie Mauresmo (fourth round)

• # 🇪🇪 Kaia Kanepi (third round)

• # 🇷🇺 Anna Chakvetadze (third round)

• # 🇯🇵 Ai Sugiyama (second round)

• # 🇷🇺 Alisa Kleybanova (fourth round)

• # 🇭🇺 Ágnes Szávay (fourth round)

• # 🇨🇿 Iveta Benešová (quarterfinals)

• # 🇦🇹 Sybille Bammer (second round)

• # 🇺🇦 Alona Bondarenko (second round)

• # 🇨🇦 Aleksandra Wozniak (second round)

• # 🇮🇹 Sara Errani (second round)

• # 🇪🇸 Carla Suárez Navarro (third round)

• # 🇨🇳 Peng Shuai (third round)