2009 Medibank International Sydney – Women's singles

Justine Henin was the defending champion, but retired from the sport on May 14, 2008.

Elena Dementieva won the all-Russian final, 6–3, 2–6, 6–1, over Dinara Safina.

World No. 2 and the first seed Serena Williams was nearly out of the tournament two times. Williams saved four match points in her first round clash against Samantha Stosur & three more against Caroline Wozniacki in the quarterfinals. Williams was defeated by the eventual champion Dementieva in the semifinals in straight sets.

Seeds
• # 🇺🇸 Serena Williams (semifinals)

• # 🇷🇺 Dinara Safina (final)

• # 🇷🇺 Elena Dementieva (champion)

• # 🇷🇺 Vera Zvonareva (withdrew due to gastrointestinal illness)

• # 🇷🇺 Svetlana Kuznetsova (quarterfinals, withdrew due to an abdominal strain)

• # 🇵🇱 Agnieszka Radwańska (quarterfinals)

• # 🇷🇺 Nadia Petrova (first round)

• # Caroline Wozniacki (quarterfinals)