2021 Chicago Challenger – Doubles

Mona Barthel and Kristýna Plíšková were the defending champions, but Plíšková chose not to participate.

Eri Hozumi and Peangtarn Plipuech won the title, defeating Barthel and Hsieh Yu-chieh in the final, 7–5, 6–2.

Seeds
• # 🇺🇸 Kaitlyn Christian / Lesley Pattinama Kerkhove (first round)

• # 🇩🇪 Julia Lohoff / 🇨🇿 Renata Voráčová (first round)

• # 🇬🇧 Harriet Dart / 🇺🇸 Caroline Dolehide (first round)

• # 🇮🇹 Sara Errani / Oksana Kalashnikova (first round)