2021 Dow Tennis Classic

The 2021 Dow Tennis Classic was a professional tennis tournament played on indoor hard courts. It was the twenty-seventh edition of the tournament which was part of the 2021 WTA 125 tournaments. It took place at the Greater Midland Tennis Center in Midland, Michigan, United States between 1 and 7 November 2021.

Seeds

 * 1 Rankings are as of 25 October 2021.

Other entrants
The following players received wildcards into the singles main draw:
 * 🇺🇸 Reese Brantmeier
 * 🇺🇸 Elvina Kalieva
 * 🇺🇸 Ashlyn Krueger
 * 🇺🇸 Katrina Scott

The following players received entry using protected rankings:
 * 🇰🇷 Han Na-lae
 * 🇨🇳 Lu Jiajing

The following players received entry from the qualifying draw:
 * 🇺🇸 Ellie Douglas
 * 🇺🇸 Alexa Glatch
 * 🇺🇸 Catherine Harrison
 * 🇺🇸 Dalayna Hewitt

Withdrawals

 * Before the tournament
 * 🇺🇸 Amanda Anisimova → replaced by 🇺🇸 Robin Anderson
 * 🇺🇸 Lauren Davis → replaced by 🇲🇽 Marcela Zacarías
 * 🇧🇾 Olga Govortsova → replaced by 🇺🇸 Asia Muhammad
 * Valentini Grammatikopoulou → replaced by 🇩🇪 Tatjana Maria
 * 🇦🇺 Priscilla Hon → replaced by 🇺🇸 Francesca Di Lorenzo
 * 🇯🇵 Nao Hibino → replaced by Conny Perrin
 * 🇺🇸 Ann Li → replaced by 🇺🇸 Whitney Osuigwe
 * 🇺🇸 Claire Liu → replaced by 🇺🇸 Alycia Parks
 * 🇺🇸 CoCo Vandeweghe → replaced by 🇰🇷 Han Na-lae

Seeds

 * Rankings are as of October 25, 2021

Singles

 * 🇺🇸 Madison Brengle def. 🇺🇸 Robin Anderson 6–2, 6–4

Doubles

 * 🇬🇧 Harriet Dart / 🇺🇸 Asia Muhammad def. 🇹🇭 Peangtarn Plipuech / Aldila Sutjiadi 6–3, 2–6, [10–7]