2021 Uruguay Open

The 2021 Uruguay Open was a professional tennis tournament played on red clay courts in Montevideo. It was the 16th edition of the tournament for the men which was part of the 2021 ATP Challenger Tour. It took place at the Carrasco Lawn Tennis Club in Montevideo, Uruguay between November 8 and 14, 2021. The 2020 edition could not take place due to the COVID-19 pandemic.

Seeds

 * 1 Rankings are as of 1 November 2021.

Other entrants
The following players received wildcards into the singles main draw:
 * Martín Cuevas
 * Francisco Llanes
 * Franco Roncadelli

The following players received entry into the singles main draw as alternates:
 * 🇦🇷 Hernán Casanova
 * 🇦🇷 Genaro Alberto Olivieri
 * 🇦🇷 Santiago Rodríguez Taverna

The following players received entry from the qualifying draw:
 * 🇦🇷 Francisco Comesaña
 * 🇮🇹 Luciano Darderi
 * 🇦🇷 Facundo Juárez
 * 🇦🇷 Gonzalo Villanueva

Singles

 * 🇧🇴 Hugo Dellien def. 🇦🇷 Juan Ignacio Londero 6–0, 6–1.

Doubles

 * 🇧🇷 Rafael Matos / 🇧🇷 Felipe Meligeni Alves def. Ignacio Carou / 🇮🇹 Luciano Darderi 6–4, 6–4.