Mississippi's 2nd congressional district

Mississippi's 2nd congressional district (MS-2) covers much of Western Mississippi. It includes most of Jackson, the riverfront cities of Greenville, Natchez and Vicksburg and the interior market cities of Clarksdale, Greenwood and Clinton. The district is approximately 275 mi long, 180 mi wide and borders the Mississippi River; it encompasses much of the Mississippi Delta, for a total of 28 counties plus parts of Hinds and Madison. It is the only majority-black district in the state. With a Cook Partisan Voting Index rating of D+11, it is also the only Democratic district in Mississippi.

The district is home to five of Mississippi's eight public four-year colleges and universities: Alcorn State University in Lorman; Delta State University in Cleveland; Jackson State University in Jackson; Copiah-Lincoln Community College in Wesson; and Mississippi Valley State University in Itta Bena, a few miles west of Greenwood. All except Delta State are HBCUs and are members of the Southwestern Athletic Conference.

The district is one of the poorest in Mississippi and the nation. with 26.2% of people in poverty as of 2017.

The district's current Representative is Democrat Bennie Thompson.