Missouri's 1st congressional district

Missouri's 1st congressional district is in the eastern portion of the state. It includes all of St. Louis City and much of northern St. Louis County, including the cities of Maryland Heights, University City, Ferguson and Florissant. With a Cook Partisan Voting Index rating of D+27, it is the most Democratic district in Missouri. Roughly half of the district's population is African American.

Its current representative is Democrat Cori Bush, who was elected in 2020. William Lacy Clay, Jr., had previously represented the district since 2001, succeeding his father, William Lacy Clay, Sr. Bush, a progressive and leader in the Ferguson protests, beat Clay in the August 4, 2020 primary. Bush had lost the same primary in 2018 by 20 points to Clay.