2021 Montevideo Open – Singles

This was the first edition of the women's event.

Diane Parry won the title, defeating Panna Udvardy in the final, 6–3, 6–2.

Seeds
• # 🇧🇷 Beatriz Haddad Maia (first round)

• # 🇭🇺 Anna Bondár (first round)

• # 🇭🇺 Panna Udvardy (final)

• # 🇷🇴 Irina Bara (second round)

• # 🇫🇷 Diane Parry (champion)

• # Ekaterine Gorgodze (semifinals)

• # 🇦🇷 Paula Ormaechea (second round)

• # 🇧🇷 Laura Pigossi (quarterfinals)

Seeds
• # 🇦🇺 Olivia Tjandramulia (qualified)

• # 🇺🇸 Dasha Ivanova (qualified)

• # 🇩🇪 Jasmin Jebawy (qualifying competition)

• # 🇦🇷 Martina Capurro Taborda (qualified)

Qualifiers
• # 🇦🇺 Olivia Tjandramulia

• # 🇺🇸 Dasha Ivanova

• # 🇦🇷 Marina Bulbarella

• # 🇦🇷 Martina Capurro Taborda