2021 Open Sopra Steria de Lyon

The 2021 Open Sopra Steria de Lyon was a professional tennis tournament played on clay courts. It was the 5th edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Lyon, France, between 7 and 13 June 2021.

Seeds

 * 1 Rankings are as of 31 May 2021.

Other entrants
The following players received wildcards into the singles main draw:
 * 🇫🇷 Titouan Droguet
 * 🇫🇷 Kyrian Jacquet
 * 🇫🇷 Matteo Martineau

The following player received entry into the singles main draw as a special exempt:
 * Holger Rune

The following players received entry from the qualifying draw:
 * 🇦🇷 Pedro Cachin
 * 🇫🇷 Manuel Guinard
 * 🇦🇷 Camilo Ugo Carabelli
 * 🇷🇺 Alexey Vatutin

The following players received entry as lucky losers:
 * 🇧🇪 Michael Geerts
 * 🇫🇷 Laurent Lokoli

Singles

 * Pablo Cuevas def. 🇸🇪 Elias Ymer 6–2, 6–2.

Doubles

 * Martín Cuevas / Pablo Cuevas def. 🇫🇷 Tristan Lamasine / 🇫🇷 Albano Olivetti 6–3, 7–6(7–2).