2021 Challenger de Santiago II

The 2021 Challenger de Santiago II was a professional tennis tournament played on clay courts. It was the 14th edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Santiago, Chile between 4 and 10 October 2021.

Seeds

 * 1 Rankings are as of 27 September 2021.

Other entrants
The following players received wildcards into the singles main draw:
 * Diego Fernández Flores
 * Gonzalo Lama
 * Víctor Núñez

The following players received entry into the singles main draw using protected rankings:
 * 🇦🇹 Gerald Melzer
 * Gonçalo Oliveira

The following players received entry into the singles main draw as alternates:
 * 🇦🇷 Hernán Casanova
 * Lucas Catarina
 * 🇺🇸 Nick Chappell

The following players received entry from the qualifying draw:
 * 🇵🇪 Nicolás Álvarez
 * 🇺🇸 Oliver Crawford
 * 🇦🇷 Facundo Díaz Acosta
 * 🇫🇷 Alexis Gautier

The following player received entry as a lucky loser:
 * 🇨🇴 Cristian Rodríguez

Singles

 * 🇵🇪 Juan Pablo Varillas def. 🇦🇷 Sebastián Báez 6–4, 7–5.

Doubles

 * 🇪🇨 Diego Hidalgo / Nicolás Jarry def. 🇺🇸 Evan King / 🇺🇸 Max Schnur 6–3, 5–7, [10–6].