2011 US Open – Men's doubles

Bob and Mike Bryan were the defending champions, but lost in the first round to Ivo Karlović and Frank Moser. It marked the first time the Bryan brothers lost in the first round of a Grand Slam tournament since the 2001 Australian Open, a span of 42 Grand Slam tournaments, and their first opening round loss at the US Open since 1999.

Jürgen Melzer and Philipp Petzschner won the title, defeating the Polish team of Mariusz Fyrstenberg and Marcin Matkowski in the final, 6–2, 6–2.

Seeds
• # 🇺🇸 Bob Bryan / 🇺🇸 Mike Bryan (first round)

• # 🇧🇾 Max Mirnyi / 🇨🇦 Daniel Nestor (second round)

• # 🇫🇷 Michaël Llodra / 🇷🇸 Nenad Zimonjić (third round)

• # 🇮🇳 Mahesh Bhupathi / 🇮🇳 Leander Paes (quarterfinals)

• # 🇮🇳 Rohan Bopanna / 🇵🇰 Aisam-ul-Haq Qureshi (semifinals)

• # 🇵🇱 Mariusz Fyrstenberg / 🇵🇱 Marcin Matkowski (final)

• # 🇸🇪 Robert Lindstedt / 🇷🇴 Horia Tecău (quarterfinals)

• # 🇺🇸 Eric Butorac / Jean-Julien Rojer (second round)

• # 🇦🇹 Jürgen Melzer / 🇩🇪 Philipp Petzschner (champions)

• # 🇩🇪 Christopher Kas / 🇦🇹 Alexander Peya (first round)

• # 🇨🇿 František Čermák / 🇸🇰 Filip Polášek (first round)

• # 🇧🇷 Marcelo Melo / 🇧🇷 Bruno Soares (second round)

• # 🇪🇸 Marcel Granollers / 🇪🇸 Marc López (third round, withdrew)

• # 🇦🇷 Eduardo Schwank / 🇦🇷 Juan Ignacio Chela (second round)

• # Mark Knowles  / 🇧🇪 Xavier Malisse (third round)

• # 🇺🇸 Scott Lipsky / 🇺🇸 Rajeev Ram (first round)