2011 US Open – Mixed doubles

Liezel Huber and Bob Bryan were the defending champions, but they lost to Melanie Oudin and Jack Sock in the second round.

Oudin and Sock went on to win the title, defeating Gisela Dulko and Eduardo Schwank in the final 7–6(7–4), 4–6, [10–8].

Seeds
• # 🇺🇸 Liezel Huber / 🇺🇸 Bob Bryan (second round)

• # Katarina Srebotnik / 🇨🇦 Daniel Nestor (second round)

• # 🇰🇿 Yaroslava Shvedova / 🇧🇾 Max Mirnyi (first round)

• # 🇨🇿 Květa Peschke / 🇵🇰 Aisam-ul-Haq Qureshi (withdrew)

• # 🇺🇸 Vania King / 🇮🇳 Rohan Bopanna (first round)

• # 🇮🇳 Sania Mirza / 🇮🇳 Mahesh Bhupathi (first round)

• # 🇷🇺 Elena Vesnina / 🇮🇳 Leander Paes (semifinals, withdrew)

• # 🇦🇷 Gisela Dulko / 🇦🇷 Eduardo Schwank (final)