2008 US Open – Men's doubles

Simon Aspelin and Julian Knowle were the defending champions, but lost in the second round to Igor Kunitsyn and Dmitry Tursunov.

Bob Bryan and Mike Bryan won in the final 7–6(7–5), 7–6(12–10), against Lukáš Dlouhý and Leander Paes.

Seeds
• # 🇨🇦 Daniel Nestor / 🇷🇸 Nenad Zimonjić (third round)

• # 🇺🇸 Bob Bryan / 🇺🇸 Mike Bryan (champions)

• # 🇮🇱 Jonathan Erlich / 🇮🇱 Andy Ram (second round)

• # 🇮🇳 Mahesh Bhupathi / Mark Knowles (third round)

• # 🇸🇪 Jonas Björkman / Kevin Ullyett (second round)

• # 🇸🇪 Simon Aspelin / 🇦🇹 Julian Knowle (second round)

• # 🇨🇿 Lukáš Dlouhý / 🇮🇳 Leander Paes (final)

• # 🇵🇱 Mariusz Fyrstenberg / 🇵🇱 Marcin Matkowski (first round)

• # 🇦🇺 Paul Hanley / 🇦🇺 Jordan Kerr (first round)

• # 🇫🇷 Arnaud Clément / 🇫🇷 Michaël Llodra (first round, retired)

• # 🇨🇿 Martin Damm / 🇨🇿 Pavel Vízner (third round)

• # Pablo Cuevas / 🇵🇪 Luis Horna (second round)

• # Jeff Coetzee /  Rogier Wassen (first round)

• # 🇧🇾 Max Mirnyi / 🇬🇧 Jamie Murray (first round)

• # 🇧🇷 Marcelo Melo / 🇧🇷 André Sá (third round)

• # 🇫🇷 Julien Benneteau / 🇫🇷 Nicolas Mahut (second round)