2011 US Open – Women's singles

Samantha Stosur defeated Serena Williams in the final, 6–2, 6–3 to win the women's singles tennis title at the 2011 US Open. It was her first and only major singles title. Stosur became the first Australian woman to win a major since Evonne Goolagong Cawley at the 1980 Wimbledon Championships, and the first to win the US Open since Margaret Court in 1973.

Kim Clijsters was the two-time reigning champion, but withdrew due to an abdominal injury.

This was the first time in the tournament's history where no American players were among the top ten seeds.

Seeds
• Caroline Wozniacki (semifinals)

• 🇷🇺 Vera Zvonareva (quarterfinals)

•  🇷🇺 Maria Sharapova (third round)

•  🇧🇾 Victoria Azarenka (third round)

•  🇨🇿 Petra Kvitová (first round)

•  🇨🇳 Li Na (first round)

•  🇮🇹 Francesca Schiavone (fourth round)

•  🇫🇷 Marion Bartoli (second round)

•  🇦🇺 Samantha Stosur (champion)

•  🇩🇪 Andrea Petkovic (quarterfinals)

•  🇷🇸 Jelena Janković (third round)

•  🇵🇱 Agnieszka Radwańska (second round)

•  🇨🇳 Peng Shuai (fourth round)

•  🇸🇰 Dominika Cibulková (second round)

•  🇷🇺 Svetlana Kuznetsova (fourth round)

•  🇷🇸 Ana Ivanovic (fourth round)

•  🇷🇺 Anastasia Pavlyuchenkova (quarterfinals)

•  🇮🇹 Roberta Vinci (third round)

•  🇩🇪 Julia Görges (third round)

•  🇧🇪 Yanina Wickmayer (second round, retired because of a back injury)

•  🇸🇰 Daniela Hantuchová (first round)

•  🇩🇪 Sabine Lisicki (fourth round)

•  🇮🇱 Shahar Pe'er (second round)

•  🇷🇺 Nadia Petrova (third round)

•  🇷🇺 Maria Kirilenko (fourth round)

•  🇮🇹 Flavia Pennetta (quarterfinals)

•  🇨🇿 Lucie Šafářová (third round)

•  🇺🇸 Serena Williams (final)

•  🇦🇺 Jarmila Gajdošová (second round)

•  🇪🇸 Anabel Medina Garrigues (third round)

•  🇪🇪 Kaia Kanepi (second round)

•  🇪🇸 María José Martínez Sánchez (first round)