2021 US Open – Men's doubles

Rajeev Ram and Joe Salisbury defeated the defending champion Bruno Soares and his partner Jamie Murray in the final, 3–6, 6–2, 6–2 to win the men's doubles tennis title at the 2021 US Open. It was the second major title for Ram and Salisbury as a team, following the 2020 Australian Open. Ram and Salisbury saved four match points en route to the title, in the quarterfinals against Matthew Ebden and Max Purcell.

Soares and Mate Pavić were the defending champions, but did not play together. Pavić partnered Nikola Mektić, but lost in the first round to Nathaniel Lammons and Jackson Withrow.

Salisbury also won the mixed doubles title partnering Desirae Krawczyk, becoming the first man to win both the men's doubles and mixed doubles titles at the US Open in the same year since Bob Bryan in 2010.

Seeds
• Nikola Mektić / Mate Pavić (first round)

• 🇪🇸 Marcel Granollers / 🇦🇷 Horacio Zeballos (quarterfinals)

• 🇫🇷 Pierre-Hugues Herbert / 🇫🇷 Nicolas Mahut (quarterfinals)

• 🇺🇸 Rajeev Ram / 🇬🇧 Joe Salisbury (champions)

• 🇨🇴 Juan Sebastián Cabal / 🇨🇴 Robert Farah (first round)

• 🇩🇪 Kevin Krawietz / 🇷🇴 Horia Tecău (quarterfinals)

• 🇬🇧 Jamie Murray / 🇧🇷 Bruno Soares (final)

• 🇦🇺 John Peers / 🇸🇰 Filip Polášek (semifinals)

• 🇵🇱 Łukasz Kubot / 🇧🇷 Marcelo Melo (first round)

•  Wesley Koolhof /  Jean-Julien Rojer (third round)

•  Raven Klaasen / 🇯🇵 Ben McLachlan (second round)

• 🇩🇪 Tim Pütz / 🇳🇿 Michael Venus (first round, retired)

• 🇮🇳 Rohan Bopanna /  Ivan Dodig (third round)

• 🇮🇹 Simone Bolelli / 🇦🇷 Máximo González (second round)

• 🇰🇿 Andrey Golubev / 🇩🇪 Andreas Mies (third round)

• 🇧🇪 Sander Gillé / 🇧🇪 Joran Vliegen (second round)

Wild card entries
• 🇺🇸 Christopher Eubanks / 🇺🇸 Bjorn Fratangelo

• 🇺🇸 Robert Galloway / 🇺🇸 Alex Lawson

• 🇺🇸 Steve Johnson / 🇺🇸 Sam Querrey

• 🇺🇸 Evan King / 🇺🇸 Hunter Reese

• 🇺🇸 Mitchell Krueger / 🇺🇸 Michael Mmoh

• 🇺🇸 Nathaniel Lammons / 🇺🇸 Jackson Withrow

• 🇺🇸 Eliot Spizzirri / 🇺🇸 Tyler Zink

Alternates
• 🇰🇷 Kwon Soon-woo / 🇮🇳 Divij Sharan

• Frederik Nielsen / 🇨🇦 Vasek Pospisil

Withdrawals

 * Before the tournament
 * Nikoloz Basilashvili / 🇧🇾 Andrei Vasilevski → replaced by 🇰🇷 Kwon Soon-woo / 🇮🇳 Divij Sharan
 * Aljaž Bedene / 🇷🇸 Laslo Đere → replaced by 🇷🇸 Laslo Đere / 🇷🇸 Filip Krajinović
 * 🇰🇿 Alexander Bublik / 🇪🇸 David Vega Hernández → replaced by Frederik Nielsen / 🇨🇦 Vasek Pospisil
 * 🇦🇺 James Duckworth / 🇯🇵 Yoshihito Nishioka → replaced by 🇦🇺 James Duckworth / 🇦🇺 Jordan Thompson
 * 🇦🇹 Jürgen Melzer / 🇫🇷 Jo-Wilfried Tsonga → replaced by 🇦🇹 Jürgen Melzer / 🇦🇺 Marc Polmans