2022 US Open – Men's doubles

Defending champions Rajeev Ram and Joe Salisbury defeated Wesley Koolhof and Neal Skupski in the final, 7–6(7–4), 7–5 to win the men's doubles tennis title at the 2022 US Open. They became the second team in the Open Era to defend the US Open title, after Todd Woodbridge and Mark Woodforde in 1996. It was both men's fifth major title.

Salisbury retained his ATP number 1 doubles ranking by winning the championship. Michael Venus, Horacio Zeballos, Mate Pavić, Jean-Julien Rojer, and Skupski were also in contention for the top ranking.

This tournament marked the final professional appearance of former doubles world No. 2 and six-time doubles major champion Bruno Soares; partnering with Jamie Murray, he lost in the second round to Hugo Nys and Jan Zieliński.

This is the first edition of US Open to feature a 10-point tie-break, when the score reaches six games all in the deciding set. Marcelo Demoliner and João Sousa defeated Marcel Granollers and Zeballos in the first round in the first main-draw 10-point tie-break at US Open.

Seeds
• 🇺🇸 Rajeev Ram / 🇬🇧 Joe Salisbury (champions)

• Wesley Koolhof / 🇬🇧 Neal Skupski (final)

•  Marcelo Arévalo /  Jean-Julien Rojer (semifinals)

• 🇩🇪 Tim Pütz / 🇳🇿 Michael Venus (third round)

• 🇪🇸 Marcel Granollers / 🇦🇷 Horacio Zeballos (first round)

•  Nikola Mektić /  Mate Pavić (quarterfinals)

•  Ivan Dodig / 🇺🇸 Austin Krajicek (second round)

• 🇦🇺 Thanasi Kokkinakis / 🇦🇺 Nick Kyrgios (third round)

• 🇮🇳 Rohan Bopanna /  Matwé Middelkoop (first round)

• 🇬🇧 Jamie Murray / 🇧🇷 Bruno Soares (second round)

• 🇬🇧 Lloyd Glasspool / 🇫🇮 Harri Heliövaara (quarterfinals)

• 🇩🇪 Kevin Krawietz / 🇩🇪 Andreas Mies (second round)

• 🇨🇴 Juan Sebastián Cabal / 🇨🇴 Robert Farah (semifinals)

• 🇲🇽 Santiago González / 🇦🇷 Andrés Molteni (first round)

• 🇮🇹 Simone Bolelli / 🇮🇹 Fabio Fognini (third round)

• 🇫🇷 Nicolas Mahut / 🇫🇷 Édouard Roger-Vasselin (first round)

Wild cards
• 🇺🇸 Sebastian Gorzny / 🇺🇸 Alex Michelsen

• 🇺🇸 Christopher Eubanks / 🇺🇸 Ben Shelton

• 🇺🇸 Robert Galloway / 🇺🇸 Alex Lawson

• 🇺🇸 Nicholas Godsick / 🇺🇸 Ethan Quinn

• 🇺🇸 Brandon Holt / 🇺🇸 Govind Nanda

• 🇺🇸 Nicholas Monroe / 🇺🇸 Keegan Smith

• 🇺🇸 Hunter Reese / 🇺🇸 Max Schnur

Protected ranking
• Aljaž Bedene / 🇫🇮 Emil Ruusuvuori

• 🇧🇷 Marcelo Demoliner /  João Sousa

• 🇧🇪 Sander Gillé / 🇵🇱 Łukasz Kubot

• 🇯🇵 Ben McLachlan /  Franko Škugor

Alternates
• 🇩🇪 Daniel Altmaier / 🇧🇷 Thiago Monteiro

• Petros Tsitsipas /  Stefanos Tsitsipas

Withdrawals

 * Before the tournament
 * 🇦🇷 Pedro Cachin / 🇦🇷 Francisco Cerúndolo → replaced by Petros Tsitsipas /  Stefanos Tsitsipas
 * 🇪🇸 Roberto Carballés Baena / 🇪🇸 Pablo Carreño Busta → replaced by 🇦🇷 Federico Coria / 🇨🇴 Cristian Rodríguez
 * 🇫🇷 Sadio Doumbia / 🇫🇷 Fabien Reboul → replaced by 🇪🇨 Diego Hidalgo / 🇫🇷 Fabien Reboul
 * 🇺🇸 Tommy Paul / 🇺🇸 Jack Sock → replaced by 🇩🇪 Daniel Altmaier / 🇧🇷 Thiago Monteiro
 * 🇦🇷 Diego Schwartzman / 🇦🇷 Camilo Ugo Carabelli → replaced by Nikoloz Basilashvili / 🇲🇽 Hans Hach Verdugo