2010 US Open – Men's doubles

Lukáš Dlouhý and Leander Paes were the defending champions, but lost in the first round to Martin Damm and Filip Polášek 6–7(7–9), 6–3, 6–4.

Bob and Mike Bryan won in the final 7–6(7–5), 7–6(7–4), against Rohan Bopanna and Aisam-ul-Haq Qureshi.

Seeds
• # 🇺🇸 Bob Bryan / 🇺🇸 Mike Bryan (champions)

• # 🇨🇦 Daniel Nestor / 🇷🇸 Nenad Zimonjić (third round)

• # 🇨🇿 Lukáš Dlouhý / 🇮🇳 Leander Paes (first round)

• # 🇮🇳 Mahesh Bhupathi / 🇧🇾 Max Mirnyi (second round)

• # 🇵🇱 Łukasz Kubot / 🇦🇹 Oliver Marach (quarterfinals)

• # 🇨🇿 František Čermák / 🇸🇰 Michal Mertiňák (first round)

• # 🇦🇹 Jürgen Melzer / 🇩🇪 Philipp Petzschner (first round)

• # 🇦🇹 Julian Knowle / 🇮🇱 Andy Ram (first round)

• # 🇵🇱 Mariusz Fyrstenberg / 🇵🇱 Marcin Matkowski (quarterfinals)

• # Wesley Moodie / 🇧🇪 Dick Norman (quarterfinals)

• # 🇫🇷 Julien Benneteau / 🇫🇷 Michaël Llodra (second round, withdrew due to both players' injuries)

• # 🇪🇸 Marcel Granollers / 🇪🇸 Tommy Robredo (semifinals)

• # 🇸🇪 Robert Lindstedt / 🇷🇴 Horia Tecău (third round)

• # 🇸🇪 Simon Aspelin / 🇦🇺 Paul Hanley (quarterfinals)

• # 🇺🇸 Mardy Fish / Mark Knowles (third round)

• # 🇮🇳 Rohan Bopanna / 🇵🇰 Aisam-ul-Haq Qureshi (final)