2012 Delray Beach International Tennis Championships – Singles

Juan Martín del Potro was the defending champion, but chose to compete in Dubai instead. Kevin Anderson won the title after defeating Marinko Matosevic 6–4, 7–6(7–2) in the final.

Seeds
• # 🇺🇸 John Isner (semifinals)

• # Marin Čilić (first round)

• # 🇷🇸 Viktor Troicki (first round)

• # 🇺🇸 Andy Roddick (quarterfinals)

• # 🇩🇪 Philipp Kohlschreiber (quarterfinals)

• # 🇷🇺 Alex Bogomolov Jr. (second round)

• # Kevin Anderson (champion)

• # 🇦🇺 Bernard Tomic (quarterfinals)

Seeds
• # 🇨🇦 Vasek Pospisil (first round)

• # 🇺🇸 Bobby Reynolds (second round)

• # Izak van der Merwe (second round)

• # 🇺🇸 Jesse Levine (Main draw)

• # 🇬🇧 James Ward (first round)

• # 🇦🇺 Marinko Matosevic (qualified)

• # 🇺🇸 Michael Yani (qualified)

• # 🇦🇺 Greg Jones (withdrew because of a knee injury)

Qualifiers
• # 🇦🇺 Marinko Matosevic

• # 🇺🇸 Michael Yani

• # 🇺🇸 Austin Krajicek

• # 🇺🇸 Tim Smyczek