2012 Winston-Salem Open

The 2012 Winston-Salem Open was a tennis tournament played on outdoor hard courts. It was the 44th edition of the Winston-Salem Open, and was part of the ATP World Tour 250 Series of the 2012 ATP World Tour. It took place at the Wake Forest University in Winston-Salem, North Carolina, United States, from August 19 through August 25, 2012. It was the last event on the 2012 US Open Series before the 2012 US Open. John Isner won the singles title.

Seeds

 * Seedings are based on the rankings of August 13, 2012

Other entrants
The following players received wildcards into the singles main draw:
 * 🇨🇿 Tomáš Berdych
 * 🇺🇸 James Blake
 * 🇺🇸 Ryan Harrison
 * 🇦🇷 David Nalbandian

The following players received entry from the qualifying draw:
 * 🇩🇪 Benjamin Becker
 * Ernests Gulbis
 * 🇺🇸 Michael McClune
 * 🇺🇦 Sergiy Stakhovsky

Withdrawals

 * 🇫🇷 Gaël Monfils (knee injury)

Retirements

 * 🇨🇾 Marcos Baghdatis (lower back injury)

Seeds

 * Rankings are as of August 13, 2012

Other entrants
The following pair received wildcard into the doubles main draw: The following pair received entry as alternates:
 * 🇮🇱 Jonathan Erlich / 🇮🇱 Andy Ram
 * 🇪🇸 Pablo Andújar / 🇦🇷 Leonardo Mayer

Withdrawals

 * 🇨🇾 Marcos Baghdatis (lower back injury)

Retirements

 * 🇫🇷 Nicolas Mahut (knee injury)

Singles
🇺🇸 John Isner defeated 🇨🇿 Tomáš Berdych, 3–6, 6–4, 7–6(11–9)
 * It was Isner's 2nd title of the year and 5th of his career.

Doubles
🇲🇽 Santiago González / 🇺🇸 Scott Lipsky defeated 🇪🇸 Pablo Andújar / 🇦🇷 Leonardo Mayer, 6–3, 4–6, [10–2]
 * It was Gonzalez's 2nd title of the year and 5th of his career. It was Lipsky's 2nd title of the year and 8th of his career. As a team, it was their 2nd title of the year and 3rd of their career together.