2012 US Open – Mixed doubles

Melanie Oudin and Jack Sock were the defending champions, but were defeated by Sania Mirza and Colin Fleming in the second round.

Ekaterina Makarova and Bruno Soares won the title, defeating Květa Peschke and Marcin Matkowski in the final 6–7(8–10), 6–1, [12–10].

Kim Clijsters played her final professional match before her retirement later this year in this tournament, partnering Bob Bryan. The pair were defeated by Makarova and Soares in the second round. Clijsters would return to professional tennis in 2020.

Seeds
• # 🇺🇸 Liezel Huber / 🇧🇾 Max Mirnyi (semifinals)

• # 🇺🇸 Lisa Raymond / 🇺🇸 Mike Bryan (first round)

• # 🇷🇺 Elena Vesnina / 🇮🇳 Leander Paes (quarterfinals)

• # 🇨🇿 Květa Peschke / 🇵🇱 Marcin Matkowski (final)

• # Katarina Srebotnik / 🇷🇸 Nenad Zimonjić (first round)

• # 🇨🇿 Andrea Hlaváčková / 🇮🇳 Mahesh Bhupathi (second round, withdrew)

• # 🇨🇿 Lucie Hradecká / 🇨🇿 František Čermák (semifinals)

• # 🇵🇱 Klaudia Jans-Ignacik / 🇵🇱 Mariusz Fyrstenberg (second round)