2012 Italian Open – Men's singles

Rafael Nadal defeated the defending champion Novak Djokovic in a rematch of the previous year's final, 7–5, 6–3 to win the men's singles tennis title at the 2012 Italian Open. It was his record-extending sixth Italian Open title. He did not lose a set during the tournament.

Seeds
The top eight seeds receive a bye into the second round.

🇷🇸 Novak Djokovic (final) 🇪🇸 Rafael Nadal (champion) Roger Federer (semifinals) 🇬🇧 Andy Murray (third round) 🇫🇷 Jo-Wilfried Tsonga (quarterfinals) 🇪🇸 David Ferrer (semifinals) 🇨🇿 Tomáš Berdych (quarterfinals) 🇷🇸 Janko Tipsarević (second round) 🇺🇸 John Isner (second round) 🇦🇷 Juan Martín del Potro (third round) 🇫🇷 Gilles Simon (third round) 🇪🇸 Nicolás Almagro (third round) 🇫🇷 Gaël Monfils (second round) 🇦🇷 Juan Mónaco (third round) 🇪🇸 Feliciano López (first round) 🇫🇷 Richard Gasquet (quarterfinals)

Seeds
• # 🇪🇸 Albert Ramos (qualified)

• # Robin Haase (qualified)

• # 🇰🇿 Mikhail Kukushkin (qualifying competition)

• # 🇨🇴 Santiago Giraldo (qualified)

• # 🇱🇺 Gilles Müller (qualifying competition, withdrew)

• # 🇨🇴 Alejandro Falla (first round)

• # 🇯🇵 Go Soeda (first round)

• # Ivo Karlović (qualifying competition)

• # 🇺🇸 Ryan Harrison (first round)

• # 🇪🇸 Albert Montañés (first round)

• # 🇦🇺 Matthew Ebden (first round)

• # 🇧🇪 Xavier Malisse (qualifying competition)

• # 🇺🇸 Sam Querrey (qualified)

• # 🇷🇺 Igor Andreev (withdrew because of a right shoulder injury)

Qualifiers
• # 🇪🇸 Albert Ramos

• # Robin Haase

• # 🇺🇸 Sam Querrey

• # 🇨🇴 Santiago Giraldo

• # 🇷🇴 Adrian Ungur

• # 🇪🇸 Guillermo García López

• # Blaž Kavčič