2012 U.S. Men's Clay Court Championships – Singles

Ryan Sweeting was the defending champion but lost to John Isner in the quarterfinals. Isner lost in the final to Juan Mónaco, 2–6, 6–3, 3–6.

Seeds
The top four seeds receive a bye into the second round. • # 🇺🇸 Mardy Fish (second round)

• # 🇺🇸 John Isner (final)

• # 🇪🇸 Feliciano López (semifinals)

• # 🇦🇷 Juan Mónaco (champion)

• # Kevin Anderson (quarterfinals)

• # 🇦🇷 Carlos Berlocq (quarterfinals, retired)

• # 🇷🇺 Alex Bogomolov Jr. (first round)

• # Ivo Karlović (first round)

Seeds
• # 🇯🇵 Go Soeda (qualified)

• # 🇦🇷 Horacio Zeballos (qualified)

• # 🇧🇷 Ricardo Mello (qualified)

• # 🇺🇸 Michael Russell (qualified)

• # 🇩🇪 Tommy Haas (qualifying competition, withdrew due to a right knee injury)

• # 🇷🇺 Teymuraz Gabashvili (second round)

• # 🇯🇵 Yūichi Sugita (second round)

• # 🇺🇸 Michael Yani (second round, retired)

Qualifiers
• # 🇯🇵 Go Soeda

• # 🇦🇷 Horacio Zeballos

• # 🇧🇷 Ricardo Mello

• # 🇺🇸 Michael Russell