2012 Open de Nice Côte d'Azur – Singles

Nicolás Almagro successfully defended his title defeating Brian Baker 6–3, 6–2 in the final.

Seeds
The top four seeds received a bye into the second round. • # 🇺🇸 John Isner (quarterfinals)

• # 🇫🇷 Gilles Simon (semifinals)

• # 🇪🇸 Nicolás Almagro (champion)

• # 🇫🇷 Gaël Monfils (second round)

• # 🇦🇺 Bernard Tomic (second round)

• # Robin Haase (first round)

• # 🇺🇿 Denis Istomin (second round)

• # 🇮🇹 Fabio Fognini (first round)

Seeds
• # 🇧🇷 Thomaz Bellucci (qualified)

• # 🇮🇹 Flavio Cipolla (first round)

• # 🇹🇳 Malek Jaziri (first round)

• # 🇺🇸 Sam Querrey (qualified)

• # 🇩🇪 Cedrik-Marcel Stebe (qualifying competition)

• # 🇧🇬 Grigor Dimitrov (qualified)

• # 🇨🇦 Vasek Pospisil (first round)

• # 🇷🇴 Victor Hănescu (first round)

Qualifiers
• # 🇧🇷 Thomaz Bellucci

• # 🇧🇬 Grigor Dimitrov

• # 🇺🇸 Brian Baker

• # 🇺🇸 Sam Querrey