2012 Campbell's Hall of Fame Tennis Championships – Singles

John Isner successfully defended his title by beating Lleyton Hewitt 7–6(7–1), 6–4 in the final.

Seeds
• # 🇺🇸 John Isner (champion)

• # 🇯🇵 Kei Nishikori (quarterfinals)

• # 🇨🇦 Milos Raonic (second round)

• # 🇺🇿 Denis Istomin (first round)

• # 🇷🇺 Alex Bogomolov Jr. (first round)

• # 🇺🇸 Ryan Harrison (semifinals)

• # 🇺🇸 Donald Young (first round)

• # 🇱🇺 Gilles Müller (first round)

Seeds
• # 🇩🇪 Benjamin Becker (qualified)

• # 🇧🇷 Ricardo Mello (second round)

• # Izak van der Merwe (qualified)

• # 🇺🇦 Sergei Bubka (qualified)

• # 🇹🇭 Danai Udomchoke (qualifying competition)

• # 🇫🇷 Adrian Mannarino (qualifying competition)

• # 🇬🇧 James Ward (first round)

• # 🇺🇸 Denis Kudla (first round)

Qualifiers
• # 🇩🇪 Benjamin Becker

• # 🇺🇸 Tim Smyczek

• # Izak van der Merwe

• # 🇺🇦 Sergei Bubka