2012 Regions Morgan Keegan Championships – Singles

Andy Roddick was the defending champion, but lost in the first round to Xavier Malisse. Jürgen Melzer defeated Milos Raonic in the final 7–5, 7–6(7–4).

Seeds
• # 🇺🇸 John Isner (quarterfinals)

• # 🇺🇸 Andy Roddick (first round)

• # 🇨🇿 Radek Štěpánek (semifinals)

• # 🇨🇦 Milos Raonic (final)

• # 🇷🇺 Alex Bogomolov Jr. (first round)

• # 🇫🇷 Julien Benneteau (first round)

• # Kevin Anderson (second round)

• # 🇦🇺 Bernard Tomic (first round)

Seeds
• # 🇦🇺 Matthew Ebden (qualifying competition)

• # 🇩🇪 Tobias Kamke (first round)

• # 🇺🇸 Michael Russell (first round)

• # 🇨🇦 Vasek Pospisil (first round)

• # 🇺🇸 Bobby Reynolds (qualified)

• # Izak van der Merwe (first round, retired due to an ankle injury)

• # 🇺🇸 Jesse Levine (qualified)

• # 🇬🇧 James Ward (first round)

Qualifiers
• # 🇺🇸 Bobby Reynolds

• # 🇺🇸 Robert Kendrick

• # 🇺🇸 Robby Ginepri

• # 🇺🇸 Jesse Levine