2012 Sony Ericsson Open – Men's singles

Defending champion Novak Djokovic defeated Andy Murray in the final, 6–1, 7–6(7–4) to win the men's singles tennis title at the 2012 Miami Open. It was his third Miami Open title. He did not lose a single set in the entire tournament.

Seeds
All seeds received a bye into the second round.

🇷🇸 Novak Djokovic (champion) 🇪🇸 Rafael Nadal (semifinals, withdrew because of a left knee injury) Roger Federer (third round) Andy Murray (final) 🇪🇸 David Ferrer (quarterfinals) 🇫🇷 Jo-Wilfried Tsonga (quarterfinals) 🇨🇿 Tomáš Berdych (third round) 🇺🇸 Mardy Fish (quarterfinals) 🇷🇸 Janko Tipsarević (quarterfinals) 🇺🇸 John Isner (third round) 🇦🇷 Juan Martín del Potro (fourth round) 🇪🇸 Nicolás Almagro (fourth round) 🇫🇷 Gilles Simon (fourth round) 🇫🇷 Gaël Monfils (third round) 🇪🇸 Feliciano López (second round) 🇯🇵 Kei Nishikori (fourth round) 🇫🇷 Richard Gasquet (fourth round) 🇺🇦 Alexandr Dolgopolov (third round) 🇩🇪 Florian Mayer (fourth round) 🇪🇸 Fernando Verdasco (third round) 🇦🇷 Juan Mónaco (semifinals) 🇦🇹 Jürgen Melzer (third round) Marin Čilić (third round) 🇪🇸 Marcel Granollers (second round) 🇨🇿 Radek Štěpánek (third round) 🇨🇦 Milos Raonic (third round, withdrew because of a sprained right ankle) 🇷🇸 Viktor Troicki (third round) Kevin Anderson (third round) 🇦🇷 Juan Ignacio Chela (second round) 🇫🇷 Julien Benneteau (third round) 🇺🇸 Andy Roddick (fourth round) 🇩🇪 Philipp Kohlschreiber (third round)

Seeds
• # 🇫🇷 Édouard Roger-Vasselin (qualified)

• # 🇩🇪 Tobias Kamke (qualifying competition, lucky loser)

• # 🇪🇸 Guillermo García López (qualified)

• # 🇩🇪 Matthias Bachinger (qualifying competition)

• # 🇫🇷 Benoît Paire (qualifying competition)

• # 🇮🇹 Paolo Lorenzi (qualifying competition)

• # 🇫🇷 Éric Prodon (first round)

• # 🇷🇺 Igor Andreev (first round)

• # 🇺🇸 Wayne Odesnik (withdrew because of an abdominal injury)

• # 🇹🇷 Marsel İlhan (first round)

• # 🇮🇹 Simone Bolelli (qualified)

• # 🇩🇪 Björn Phau (qualified)

• # 🇺🇸 Bobby Reynolds (qualifying competition)

• # 🇧🇷 Rogério Dutra da Silva (first round)

• # Rik de Voest (first round)

• # 🇧🇷 Ricardo Mello (first round)

• # 🇪🇪 Jürgen Zopp (first round, retired because of an ankle injury)

• # 🇦🇷 Horacio Zeballos (first round)

• # Thomas Schoorel (first round)

• # 🇺🇸 Michael Russell (qualifying competition)

• # Grega Žemlja (first round, retired because of illness)

• # Paul Capdeville (qualifying competition)

• # 🇷🇺 Teymuraz Gabashvili (withdrew because of a knee injury)

• # 🇰🇿 Andrey Golubev (first round)

Qualifiers
• # 🇫🇷 Édouard Roger-Vasselin

• # Antonio Veić

• # 🇪🇸 Guillermo García López

• # 🇺🇸 Rajeev Ram

• # 🇧🇪 David Goffin

• # 🇪🇸 Roberto Bautista Agut

• # 🇫🇷 Guillaume Rufin

• # 🇫🇷 Arnaud Clément

• # 🇨🇦 Frank Dancevic

• # 🇺🇦 Sergei Bubka

• # 🇮🇹 Simone Bolelli

• # 🇩🇪 Björn Phau

Lucky losers

 * 1) 🇩🇪 Tobias Kamke