2012 Australian Open – Men's singles

Defending champion Novak Djokovic defeated Rafael Nadal in the final, 5–7, 6–4, 6–2, 6–7(5–7), 7–5 to win the men's singles tennis title at the 2012 Australian Open. It was his third Australian Open title and fifth major title overall. The final lasted 5 hours and 53 minutes, which is the longest match in Australian Open history and the longest major singles final of all time. It is considered by many to be one of the greatest matches in tennis history.

This edition of the tournament saw the top four seeds advance to the semifinals. It is also the last major, and tournament overall, in which all of the Big Four made it to the semifinals.

This was the last major appearance for former world No. 3 Ivan Ljubičić. It was also the last Australian Open for former world No. 1s Andy Roddick and Juan Carlos Ferrero, and for former world No. 3 David Nalbandian.

Seeds
• Novak Djokovic (champion)

• 🇪🇸 Rafael Nadal (final)

• Roger Federer (semifinals)

• 🇬🇧 Andy Murray (semifinals)

• 🇪🇸 David Ferrer (quarterfinals)

• 🇫🇷 Jo-Wilfried Tsonga (fourth round)

• 🇨🇿 Tomáš Berdych (quarterfinals)

• 🇺🇸 Mardy Fish (second round)

• 🇷🇸 Janko Tipsarević (third round)

• 🇪🇸 Nicolás Almagro (fourth round)

• 🇦🇷 Juan Martín del Potro (quarterfinals)

• 🇫🇷 Gilles Simon (second round)

• 🇺🇦 Alexandr Dolgopolov (third round)

• 🇫🇷 Gaël Monfils (third round)

• 🇺🇸 Andy Roddick (second round, Retired because of a hamstring injury)

• 🇺🇸 John Isner (third round)

• 🇫🇷 Richard Gasquet (fourth round)

• 🇪🇸 Feliciano López (fourth round)

• 🇷🇸 Viktor Troicki (second round)

• 🇩🇪 Florian Mayer (withdrew because of a hip strain, replaced by Rik de Voest)

•  Stan Wawrinka (third round)

• 🇪🇸 Fernando Verdasco (first round)

• 🇨🇦 Milos Raonic (third round)

• 🇯🇵 Kei Nishikori (quarterfinals)

• 🇦🇷 Juan Mónaco (first round)

• 🇪🇸 Marcel Granollers (second round)

• 🇦🇷 Juan Ignacio Chela (third round)

•  Ivan Ljubičić (first round)

• 🇨🇿 Radek Štěpánek (first round)

•  Kevin Anderson (third round)

• 🇦🇹 Jürgen Melzer (first round)

• 🇷🇺 Alex Bogomolov Jr. (second round)